Medicinal Inorganic Chemistry
Our research focus:
We are developing new metal-based drugs that specifically target cancer with high efficacy and low levels of side effects. To do this, we design and synthesize novel metal complexes and study how their fundamental chemical properties lead to their activity in biological systems. To understand these mechanisms of action we use a variety of chemical, biochemical, and spectroscopic methods..
We are developing new metal-based drugs that specifically target cancer with high efficacy and low levels of side effects. To do this, we design and synthesize novel metal complexes and study how their fundamental chemical properties lead to their activity in biological systems. To understand these mechanisms of action we use a variety of chemical, biochemical, and spectroscopic methods..
Specific areas of research:
- Design and synthesis of new metal-based anticancer drugs targeting specific biomolecule interactions
- Mechanisms and biological interactions of metal-based anticancer compounds
- Development of redox-activated metal-based anticancer compounds for tumour targeting
- Application of magnetic resonance methods to study mechanisms of metallodrug candidates
- Structure and Reactivity of paramagnetic species, such as radicals, spin traps, reactive oxygen species suing EPR and NMR
Techniques:
We combine inorganic synthesis, chemical biology and spectroscopy to relate the structures of metal centres to reactivity. Many of the systems we study are paramagnetic, and we use electron paramagnetic resonance (EPR) and electron-nuclear double resonance (ENDOR) to study paramagnetic metal centres and radical chemistry. We also use NMR and MRI extensively to characterize the biological behaviour of metallodrug candidates.
We combine inorganic synthesis, chemical biology and spectroscopy to relate the structures of metal centres to reactivity. Many of the systems we study are paramagnetic, and we use electron paramagnetic resonance (EPR) and electron-nuclear double resonance (ENDOR) to study paramagnetic metal centres and radical chemistry. We also use NMR and MRI extensively to characterize the biological behaviour of metallodrug candidates.
We are privileged to conduct research on the unceded traditional territories of the xʷməθkʷəy̓əm (Musqueam), Sḵwx̱wú7mesh Úxwumixw (Squamish), səl̓ilw̓ətaʔɬ (Tsleil-Waututh), q̓íc̓əy̓ (Katzie), kʷikʷəƛ̓əm (Kwikwetlem), Qayqayt, Kwantlen, Semiahmoo, and Tsawwassen peoples.
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